Chemical assay-guided natural product isolation via solid-supported chemodosimetric fluorescent probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00360a Click here for additional data file.

Chemical assay-guided natural product isolation via solid-supported chemodosimetric fluorescent probe.

As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry ...

In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05712h Click here for additional data file.

Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding† †Electronic supplementary information (ESI) available: Experimental procedures (microbiology and chemical synthesis), fluorescence emission spectra and X-ray crystallographic data. See DOI: 10.1039/b614557d Click here for additional data file. Click here for additional data file.

The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

First total synthesis of concavine† †Electronic supplementary information (ESI) available. CCDC 1523963. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05627j Click here for additional data file. Click here for additional data file.

The synthesis of the unusual alkaloid concavine, isolated from Clitocybe concava (Basidiomycetae), has been accomplished. The synthetic route features regioand stereoselective manipulation of polycyclic imide intermediates via enolate substitution and Grignard addition, along with a key bridge-forming step involving a new method for sulfenylative radical cyclisation. The NMR data for synthetic ...

A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells† †Electronic supplementary information (ESI) available: Experimental details for chemical synthesis of all compounds, chemical structure characterization, supplementary spectra of probe, and fluorescence imaging methods and data. See DOI: 10.1039/c7sc00423k Click here for additional data file.